Efflux pumps in drug resistance of Mycobacterium tuberculosis: A panoramic view
نویسندگان
چکیده
Tuberculosis (TB) disease occurs in every part of the world and large numbers of cases have been noted from all over the world. About one third of the population has TB infection and millions of people are dying every year. The disease is caused by Mycobacterium tuberculosis (MTB) which usually attacks lungs but can infect other organs also. In the current situation, the major problem in treating this disease is emergence of Multidrug resistance (MDRTB) and Extensive drug resistance (XDRTB) strains, which remains a critical but largely unresolved issue. MDR-TB refers to the TB bacteria which are resistant to first line drugs such as isoniazid and rifampicin, while XDR-TB refers to the TB bacteria which are resistant to fluoroquinolone (FQ) in addition to isoniazid and rifampicin and to at least one of the second line drugs like ISSN: 2319-7706 Volume 3 Number 8 (2014) pp. 528-546 http://www.ijcmas.com
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